New research just keeps on coming!
Here are very exciting potential breakthrough articles well worth reading. Article #3 reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells. Article #5 has found that nerves play a critical role in both the development and spread of prostate tumors. Article #6 has found a new drug called pyrvinium pamoate that inhibits aggressive forms of prostate cancer that are resistant to standard drugs.
My hope for finding a cure for prostate cancer gets a big boast knowing that so many researchers are working around the clock to find a cure!
1) Researchers reveal that proteins delivering leucine to prostate cancer cells may offer therapeutic targets
Like normal cells, cancer cells require amino acids for growth, maintenance, and cell signaling, and L-type amino acid transporters (LATs) are the delivery vehicles that supply them. Metastatic, castration-resistant prostate cancer (CRPC) cells are highly dependent on LATs to deliver the amino acid leucine that the cells need for growth and proliferation.
2) Depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation – possible new approach to prostate cancer treatment
A study in the Journal of Biological Chemistry identifies a new therapeutic approach to treat prostate cancer. Conducted at Cincinnati Children’s Hospital Medical Center, the research shows that expression of the FoxM1 protein is essential for prostate cancer to develop. The study also shows that depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation, the process by which new blood vessels are formed, and metastasis – the spread of cancer to other organs of the body.
3) Researchers uncover how SMIP004 kills prostate cancer cells
One major hallmark of cancer cells is their ability to survive under stressful conditions. A new study spearheaded by researchers at Sanford-Burnham Medical Research Institute reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress.
4) How The Heating Effect In Magnetic Hyperthermia Works In Prostate Cancer Treatment
Physicists from the University of York have carried out new research into how the heating effect of an experimental cancer treatment works.Magnetic hyperthermia is viewed as an attractive approach for the treatment of certain cancers as it has no known side effects compared to more conventional therapies such as chemotherapy. It is particularly suitable for the treatment of prostate cancer.
5) In Prostate Cancer Nerves Play Key Role In Development And Metastasis
Researchers at Albert Einstein College of Medicine of Yeshiva University have found that nerves play a critical role in both the development and spread of prostate tumors. Their findings, using both a mouse model and human prostate tissue, may lead to new ways to predict the aggressiveness of prostate cancer and to novel therapies for preventing and treating the disease.
6) Drug-Resistant Prostate Cancer Treated With New Medication In The Laboratory
A new drug called pyrvinium pamoate inhibits aggressive forms of prostate cancer that are resistant to standard drugs, “Our novel prostate cancer drug works by a unique mechanism of action,” said study lead author Jeremy Jones, PhD, assistant professor of molecular pharmacology at City of Hope, Beckman Research Institute, in Duarte, CA. “Thus, it has the potential to treat cancers resistant to currently approved therapies.”
7) Discovery Of Source Of Tumor Growth In Aggressive Prostate Cancer
Researchers have discovered a molecular switch that explains, at least in part, how some fast-growing prostate cancers become resistant to hormone treatment, a new study conducted in human cell cultures and mice finds. The results were presented at The Endocrine Society’s 95th Annual Meeting in San Francisco.
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