(7) Very Exciting Articles on Potential Prostate Cancer Breakthroughs!

Hi Guys,

New research just keeps on coming!

Here are very exciting potential breakthrough articles well worth reading.  Article #3  reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells.  Article #5 has found that nerves play a critical role in both the development and spread of prostate tumors.  Article #6 has found a new drug called pyrvinium pamoate that inhibits aggressive forms of prostate cancer that are resistant to standard drugs.

My hope for finding a cure for prostate cancer gets a big boast knowing that so many researchers are working around the clock to find a cure!

1)  Researchers reveal that proteins delivering leucine to prostate cancer cells may offer therapeutic targets

Like normal cells, cancer cells require amino acids for growth, maintenance, and cell signaling, and L-type amino acid transporters (LATs) are the delivery vehicles that supply them. Metastatic, castration-resistant prostate cancer (CRPC) cells are highly dependent on LATs to deliver the amino acid leucine that the cells need for growth and proliferation.

Full Story: Proteins delivering leucine to prostate cancer cells

2)  Depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation – possible new approach to prostate cancer treatment

A study in the Journal of Biological Chemistry identifies a new therapeutic approach to treat prostate cancer. Conducted at Cincinnati Children’s Hospital Medical Center, the research shows that expression of the FoxM1 protein is essential for prostate cancer to develop.  The study also shows that depletion of FoxM1 in prostate epithelial cells inhibits tumor cell proliferation, the process by which new blood vessels are formed, and metastasis – the spread of cancer to other organs of the body.

Full Story: Depletion of FoxM1 in prostate epithelial cells

3)  Researchers uncover how SMIP004 kills prostate cancer cells

One major hallmark of cancer cells is their ability to survive under stressful conditions. A new study spearheaded by researchers at Sanford-Burnham Medical Research Institute reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress.

Full Story: Researchers uncover how SMIP004 kills prostate\

4)  How The Heating Effect In Magnetic Hyperthermia Works In Prostate Cancer Treatment

Physicists from the University of York have carried out new research into how the heating effect of an experimental cancer treatment works.Magnetic hyperthermia is viewed as an attractive approach for the treatment of certain cancers as it has no known side effects compared to more conventional therapies such as chemotherapy. It is particularly suitable for the treatment of prostate cancer.

Full Story: How The Heating Effect In Magnetic Hyperthermia

5)  In Prostate Cancer Nerves Play Key Role In Development And Metastasis

Researchers at Albert Einstein College of Medicine of Yeshiva University have found that nerves play a critical role in both the development and spread of prostate tumors.  Their findings, using both a mouse model and human prostate tissue, may lead to new ways to predict the aggressiveness of prostate cancer and to novel therapies for preventing and treating the disease.

Full Story: In Prostate Cancer Nerves Play Key Role In

6)  Drug-Resistant Prostate Cancer Treated With New Medication In The Laboratory

A new drug called pyrvinium pamoate inhibits aggressive forms of prostate cancer that are resistant to standard drugs,  “Our novel prostate cancer drug works by a unique mechanism of action,” said study lead author Jeremy Jones, PhD, assistant professor of molecular pharmacology at City of Hope, Beckman Research Institute, in Duarte, CA. “Thus, it has the potential to treat cancers resistant to currently approved therapies.”

Full Story: Drug-Resistant Prostate Cancer Treated With New

7)  Discovery Of Source Of Tumor Growth In Aggressive Prostate Cancer

Researchers have discovered a molecular switch that explains, at least in part, how some fast-growing prostate cancers become resistant to hormone treatment, a new study conducted in human cell cultures and mice finds. The results were presented at The Endocrine Society’s 95th Annual Meeting in San Francisco.

Full Story: Discovery Of Source Of Tumor Growth In Aggressive Prostate Cancer

God’s Greatest Gift is TIME!

Craig Becker

The New Denver Men’s Club

Blog: https://newdenvermensclub.wordpress.com/

“Men Fighting Cancer To Win”

 

 

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2 thoughts on “(7) Very Exciting Articles on Potential Prostate Cancer Breakthroughs!

  1. Craig , Great Articles! Had a nice fall in Alaska and caught some fish, that really helped with some tuition bills. The good news is that I am getting a response after only 4 weeks of adding xtandi to zytiga psa dropped from 22 to19, and no real side effects, breathing is just fine with no shortness of breath whatsoever, we will do new scans in a few months, liver function test remain in lower end of normal, I got up at 5 am to fish as well.When I did get home my local dr wanted a nuclear stress test for my heart which came out negative in the first part for any blockage, I am waiting for results of the second part.Now that I am home I am noticing the hot flash side effect a lot more, sometimes I get some complaints for turning the ac to low, but then again soon it will be winter. How are things going for you? Dan

    ________________________________

    • Hi Dan,
      Great to hear of your big drop in PSA from 22 to 19. Nice! Zytiga and Xtandi are two of the last 4 biggest and best PCa breakthroughs, (the other two are Provenge and Radium 223). I’ve been lucky enough to do all 4 of the best PCa breakthroughs. I went to Scottsdale AZ. to get on the Xtandi “Early Expanded Access” program, (This happens just after clinical trials and just before FDA release). I did very bad with Xtandi as it made my head spin and felt sick. The experience with Zytiga has offered a super drop in my PSA! This summer I did 7 chemo infusions and 15 radiations. PSA went from 99 to 13! How is that for a drop. Lots had to do with taking Zytiga too. Good Luck! Craig

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