(5) New Potential Prostate Cancer Breakthrough Articles!

Hi Guys,

New research is being conducted every day with many promising results.  We at “The New Denver Men’s Club” attempt to find these potential breakthrough articles and present them to you!

1)  3D mapping biopsy found pockets of prostate cancer previous technique had missed    Friday 7 February 2014 – 12am PST

Ultrasound-guided biopsies miss prostate cancers that are detected by the slightly more expensive and slightly more invasive 3D mapping biopsies. For example, in a 2006 study of 180 men diagnosed with early stage prostate cancer via ultrasound-guided biopsy, nearly a quarter were upgraded to a more clinically significant stage of disease after 3D mapping biopsy found pockets of cancer the first technique had missed.   http://www.medicalnewstoday.com/releases/272227.php

2)  Final results from the Phase 3 PREVAIL trial of Enzalutamide, (Xtandi) Thursday 30 January 2014

“This is a significant step forward in prostate cancer therapy for men whose cancer has progressed, despite treatment with androgen deprivation therapy” said Professor Bertrand Tombal, MD, PhD, Chairman of the Division of the Urology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCL) and European Principal Investigator for PREVAIL. “As well as the clear efficacy benefits, what impressed me most about the results is that treatment with enzalutamide delays the time to initiation of chemotherapy, a key factor in maintaining quality of life in men with advanced prostate cancer.”  http://www.medicalnewstoday.com/releases/271902.php

3)  Previously reported:  New prostate cancer model, known as RapidCaP, reveals a cancer-gene ‘switch’ that drives metastasis

“Now, Cold Spring Harbor Laboratory (CSHL) scientists have developed a new method to rapidly create much better mouse models for metastatic prostate cancer. This discovery allows scientists to investigate the causes of the disease while at the same time testing new therapeutics to treat it”.  http://www.medicalnewstoday.com/releases/271733.php

4)  New Prostate Cancer drugs may not target root cause of the disease, York scientists warn  Monday 27 January 2014

“Scientists at the University of York have discovered that a process called ‘methylation’, previously thought to drive the development of cancer, occurs in cells that are already cancerous. The findings mean therapies aimed at reversing this process might not be effective against cancer stem cells, allowing the cancer to return.  Dr Pellacani said: “To develop cancer, certain proteins found in healthy cells need to be switched off. Sometimes this is caused by methylation – a process where DNA is changed to block instructions for making a specific protein.  “There are obvious differences in the methylation of genes in prostate cancer cells and non-cancer cells. This previously suggested that the process could be driving the progression of cancer, and that this could be reversed by using specific drugs, but our research has suggested that this may not be the case.”  http://www.medicalnewstoday.com/releases/271725.php

5)  Possible explanation for link between exercise & improved prostate cancer outcomes

“Men who engage in higher levels of physical activity have been reported to have a lower risk of prostate cancer recurrence and mortality compared with men who participate in little or no physical activity. The biological mechanisms underlying this association are not known.  “Prior research has shown that men with prostate tumors containing more regularly shaped blood vessels have a more favorable prognosis compared with men with prostate tumors containing mostly irregularly shaped blood vessels,” said Erin Van Blarigan, Sc.D., assistant professor in the Department of Epidemiology and Biostatistics at the University of California, San Francisco. “In this study, we found that men who reported walking at a brisk pace had more regularly shaped blood vessels in their prostate tumors compared with men who reported walking at a less brisk pace”.  http://www.medicalnewstoday.com/releases/271429.php

Life is the death sentence, not the disease !

Craig Becker

The New Denver Men’s Club

Blog: https://newdenvermensclub.wordpress.com/
“Men Fighting Cancer To Win”


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